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Along with Reactome's events hierarchy, This function will retrieve all the events beginning from your supplied event up to the "Top level Pathway". see "Details section" for more information.

Usage

rba_reactome_event_ancestors(event_id, ...)

Arguments

event_id

Reactome event's identifier.

...

rbioapi option(s). See rba_options's arguments manual for more information on available options.

Value

List which every element is a Data frame listing your supplied event along with it's ancestor events. Because any given event can be part of more than one pathway hierarchy, the list may contain multiple data frames.

Details

By Reactome's definition, Events are the building blocks of biological processes and could be of two main classes: "Pathway" or "Reaction-like events". The events are organized in a hierarchical structure; and each event could be child or parent to another event; The hierarchy will always begin with a "Top level pathway" event. Also note that a given event could be part of more that one hierarchies.

Corresponding API Resources

"GET https://reactome.org/ContentService/data/event/id/ancestors"

References

  • Marc Gillespie, Bijay Jassal, Ralf Stephan, Marija Milacic, Karen Rothfels, Andrea Senff-Ribeiro, Johannes Griss, Cristoffer Sevilla, Lisa Matthews, Chuqiao Gong, Chuan Deng, Thawfeek Varusai, Eliot Ragueneau, Yusra Haider, Bruce May, Veronica Shamovsky, Joel Weiser, Timothy Brunson, Nasim Sanati, Liam Beckman, Xiang Shao, Antonio Fabregat, Konstantinos Sidiropoulos, Julieth Murillo, Guilherme Viteri, Justin Cook, Solomon Shorser, Gary Bader, Emek Demir, Chris Sander, Robin Haw, Guanming Wu, Lincoln Stein, Henning Hermjakob, Peter D’Eustachio, The reactome pathway knowledgebase 2022, Nucleic Acids Research, 2021;, kab1028, https://doi.org/10.1093/nar/gkab1028

  • Griss J, Viteri G, Sidiropoulos K, Nguyen V, Fabregat A, Hermjakob H. ReactomeGSA - Efficient Multi-Omics Comparative Pathway Analysis. Mol Cell Proteomics. 2020 Sep 9. doi: 10.1074/mcp. PubMed PMID: 32907876.

  • Reactome Content Services API Documentation

  • Citations note on Reactome website

See also

Other "Reactome Content Service - Queries Related to Events": rba_reactome_event_hierarchy()

Examples

# \donttest{
rba_reactome_event_ancestors("R-HSA-5673001")
# }