Search Antigens in UniProt

UniProt maps antigenic (antibody-binding) features from several sources to protein sequences. Search those mappings using one or more criteria. At least one of accession, antigen_sequence, antigen_id, ensembl_id, or match_score is required.

Usage

rba_uniprot_antigens_search(
  accession = NULL,
  antigen_sequence = NULL,
  antigen_id = NULL,
  ensembl_id = NULL,
  match_score = NULL,
  ...
)

Arguments

accession: Character: (optional) UniProtKB primary or secondary accession(s). You can supply up to 100 accession numbers.
antigen_sequence: Character: (optional) A single antigenic protein sequence of at least four residues.
antigen_id: Character: (optional) Human Protein Atlas (HPA) antigen ID. You can supply up to 20 IDs.
ensembl_id: Character: (optional) Ensembl stable transcript ID. You can supply up to 20 IDs.
match_score: Numeric: (optional) A whole number from 0 to 100 giving the minimum alignment score between the antigen sequence and target protein sequence.
...: rbioapi option(s). See rba_options's arguments manual for more information on available options.

Value

A list in which each element represents a matching UniProt entry, named by accession when available. Antigenic annotations are stored in the entry's features element.

Corresponding API Resources

"GET https://www.ebi.ac.uk/proteins/api/antigen"

References

The UniProt Consortium. (2025). UniProt: the Universal Protein Knowledgebase in 2025. Nucleic Acids Research, 53(D1), D609–D617. https://doi.org/10.1093/nar/gkae1010
Nightingale, A., Antunes, R., Alpi, E., Bursteinas, B., Gonzales, L., Liu, W., Luo, J., Qi, G., Turner, E., & Martin, M. (2017). The Proteins API: Accessing key integrated protein and genome information. Nucleic Acids Research, 45(W1), W539–W544. https://doi.org/10.1093/nar/gkx237
Proteins API Documentation
Citations note on UniProt website

Examples