Search UniProt protein sequence features

UniProt sequence features describe biologically relevant sites and regions within protein sequences. Search and retrieve these annotations using protein, gene, organism, and annotation criteria.

Usage

rba_uniprot_features_search(
  accession = NULL,
  gene = NULL,
  exact_gene = NULL,
  protein = NULL,
  reviewed = NULL,
  organism = NULL,
  taxid = NULL,
  categories = NULL,
  types = NULL,
  ...
)

Arguments

accession: Character: (optional) UniProtKB primary or secondary accession(s). You can supply up to 100 accession numbers.
gene: Character: (optional) UniProt gene name(s). You can supply up to 20 gene names. For example, if you supply "CD40", "CD40 ligand" will also be included.
exact_gene: Character: (optional) UniProt exact gene name(s). You can supply up to 20 exact gene names. For example, if you supply "CD40", "CD40 ligand" will not be included in the results.
protein: Character: (optional) UniProt protein name.
reviewed: Logical: (optional) If TRUE, return only reviewed Swiss-Prot entries. If FALSE, return only unreviewed TrEMBL entries.
organism: Character: (optional) Organism name.
taxid: Numeric: (optional) NIH-NCBI Taxon ID. You can supply up to 20 taxon IDs.
categories: Character: (optional) Sequence annotation (features) categories. Accepted values are: "MOLECULE_PROCESSING", "TOPOLOGY", "SEQUENCE_INFORMATION", "STRUCTURAL", "DOMAINS_AND_SITES", "PTM", "VARIANTS" and/or "MUTAGENESIS". You can supply up to 20 categories.
types: Character: (optional) Sequence annotation (features) types. Accepted values are: "INIT_MET", "SIGNAL", "PROPEP", "TRANSIT", "CHAIN", "PEPTIDE", "TOPO_DOM", "TRANSMEM", "DOMAIN", "REPEAT", "ZN_FING", "DNA_BIND", "REGION", "COILED", "MOTIF", "COMPBIAS", "ACT_SITE", "BINDING", "SITE", "NON_STD", "MOD_RES", "LIPID", "CARBOHYD", "DISULFID", "CROSSLNK", "VAR_SEQ", "VARIANT", "MUTAGEN", "UNSURE", "CONFLICT", "NON_CONS", "NON_TER", "HELIX", "TURN", "STRAND" and/or "INTRAMEM". You can supply up to 20 types.
...: rbioapi option(s). See rba_options's arguments manual for more information on available options.

Value

A list named by UniProt accession. Each element contains the entry metadata, sequence, and matching annotations in its features element.

Details

At least one of accession, gene, exact_gene, protein, organism, or taxid is required. The remaining arguments refine those primary criteria.

Corresponding API Resources

"GET https://www.ebi.ac.uk/proteins/api/features"

References

The UniProt Consortium. (2025). UniProt: the Universal Protein Knowledgebase in 2025. Nucleic Acids Research, 53(D1), D609–D617. https://doi.org/10.1093/nar/gkae1010
Nightingale, A., Antunes, R., Alpi, E., Bursteinas, B., Gonzales, L., Liu, W., Luo, J., Qi, G., Turner, E., & Martin, M. (2017). The Proteins API: Accessing key integrated protein and genome information. Nucleic Acids Research, 45(W1), W539–W544. https://doi.org/10.1093/nar/gkx237
Proteins API Documentation
Citations note on UniProt website

Examples

# \donttest{
rba_uniprot_features_search(accession = "Q99616")
# }
# \donttest{
rba_uniprot_features_search(gene = "cd40")
# }
# \donttest{
rba_uniprot_features_search(gene = "cd40 ligand")
# }
# \donttest{
rba_uniprot_features_search(gene = "cd40",  reviewed = TRUE)
# }
# \donttest{
rba_uniprot_features_search(accession = "Q99616",
    categories = c("MOLECULE_PROCESSING", "TOPOLOGY"))
# }
# \donttest{
rba_uniprot_features_search(accession = "Q99616", types = "DISULFID")
# }