Get Static (IntAct) Interaction Information of a Protein

Reactome maintains a locally hosted snapshot of the IntAct interactions database. Using this function, you can retrieve IntAct information for one or more proteins in two scenarios:

1. If endpoint = "details" or endpoint = "summary", retrieve detailed or summary information for the supplied accessions.

2. If endpoint = "pathways", retrieve Reactome pathways which include your supplied protein accession. Pathways with the class "TopLevelPathway" will be excluded.

Results depend on Reactome's current static interaction snapshot; a valid accession can therefore have no mapped pathways.

Usage

rba_reactome_interactors_static(
  proteins,
  endpoint = "details",
  only_diagrammed = FALSE,
  species = NULL,
  ...
)

Arguments

proteins

Character or Numeric vector: UniProt protein accession(s). If endpoint = "pathways", only a single protein accession can be supplied.

endpoint

Character: (default = "details") Can be one of:

1. "details": Return detailed information for the supplied accessions.

2. "summary": Return summary information for the supplied accessions.

3. "pathways": Return pathways containing the interacting molecules (excluding the TopLevelPathway class).

only_diagrammed

Logical: (default = FALSE) (only when endpoint = "pathways") If TRUE, pathways without diagram will be excluded.

species

Character: (optional) (only when endpoint = "pathways") The scientific name of the species to search for pathways. See rba_reactome_species or Reactome Data Schema: Entries: Species.

...

rbioapi option(s). See rba_options's arguments manual for more information on available options.

Value

An R object containing the requested interaction information. Detailed and summary queries return information for each supplied protein; pathway queries return a data frame of matching Reactome pathways.

Corresponding API Resources

"POST https://reactome.org/ContentService/interactors/static/ molecules/details"
"POST https://reactome.org/ContentService/interactors/static/ molecules/summary"
"GET https://reactome.org/ContentService/interactors/static/molecule/ {identifier}/pathways"

References

• Ragueneau, E., Gong, C., Sinquin, P., Sevilla, C., Beavers, D., Grentner, A., ... D’Eustachio, P. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Res., 54(D1), D673–D681. doi: 10.1093/nar/gkaf1223

• Griss, J., Viteri, G., Sidiropoulos, K., Nguyen, V., Fabregat, A., & Hermjakob, H. (2020). ReactomeGSA—Efficient Multi-Omics Comparative Pathway Analysis. Molecular & Cellular Proteomics, 19(12), 2115–2125. doi: 10.1074/mcp.TIR120.002155

• Reactome Content Services API Documentation

• Citations note on Reactome website

See also

Other "Reactome Content Service - Molecule Interactors": rba_reactome_interactors_psicquic()

Examples

if (FALSE) { # \dontrun{
rba_reactome_interactors_static(proteins = "Q9BXM7-1",
    endpoint = "pathways", species = "Homo sapiens")
} # }
# \donttest{
rba_reactome_interactors_static(proteins = c("Q9BXM7-1", "Q13501"),
    endpoint = "details")
# }
# \donttest{
rba_reactome_interactors_static(proteins = c("Q9BXM7-1", "Q13501"),
    endpoint = "summary")
# }