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Get Orthologous (Computationally Inferred) Events

Source: R/reactome_content.R
rba_reactome_orthology.Rd

Reactome incorporate manually curated human reactions and PANTHER's protein homology data to Computationally infer events in other eukaryotic species.

Usage

rba_reactome_orthology(event_ids, species_dbid, ...)

Arguments

event_ids

Character vector: Up to 20 human Reactome event IDs to retrieve their orthologous events.

species_dbid

Numeric: Reactome database ID (DbId) of the target species. (e.g Mus musculus is 48892). See rba_reactome_species or Reactome Data Schema: Entries: Species.

...

rbioapi option(s). See rba_options's arguments manual for more information on available options.

Value

List containing found Orthologous event(s) in your supplied species and their pertinent information.

Details

Reactome uses an orthology-based approach to project curated human events to supported non-human species. See Reactome Computationally Inferred Events for more information.

Corresponding API Resources

"POST https://reactome.org/ContentService/data/orthologies/ids/ species/{speciesId}"

References

  • Ragueneau, E., Gong, C., Sinquin, P., Sevilla, C., Beavers, D., Grentner, A., ... D’Eustachio, P. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Res., 54(D1), D673–D681. doi: 10.1093/nar/gkaf1223

  • Griss, J., Viteri, G., Sidiropoulos, K., Nguyen, V., Fabregat, A., & Hermjakob, H. (2020). ReactomeGSA—Efficient Multi-Omics Comparative Pathway Analysis. Molecular & Cellular Proteomics, 19(12), 2115–2125. doi: 10.1074/mcp.TIR120.002155

  • Reactome Content Services API Documentation

  • Citations note on Reactome website

See also

rba_reactome_analysis_species

Examples

# \donttest{
rba_reactome_orthology(event_ids = c("R-HSA-6799198", " R-HSA-72764"),
    species_dbid = 49633)
# }