Use This function to Compare human's manually-curated pathways and computationally inferred pathways (orthologous) in other species.

rba_reactome_analysis_species(
  species_dbid,
  sort_by = "ENTITIES_PVALUE",
  order = "ASC",
  resource = "TOTAL",
  p_value = 1,
  min = NULL,
  max = NULL,
  ...
)

Arguments

species_dbid

Numeric: Reactome DbId (e.g Mus musculus is 48892) of the species you want to compare with Homo sapiens. See rba_reactome_species or Reactome Data Schema: Entries: Species.

sort_by

Sort the result based on what column? available choices are: "NAME", "TOTAL_ENTITIES", "TOTAL_INTERACTORS", "TOTAL_REACTIONS", "FOUND_ENTITIES", "FOUND_INTERACTORS", "FOUND_REACTIONS", "ENTITIES_RATIO", "ENTITIES_PVALUE", "ENTITIES_FDR" or "REACTIONS_RATIO"

order

Sort Order. Can be either "ASC" (default) or "DESC".

resource

Filter results based on the resource. Default is "TOTAL", available choices are: "TOTAL", "UNIPROT", "ENSEMBL", "CHEBI", "IUPHAR", "MIRBASE", "NCBI_PROTEIN", "EMBL", "COMPOUND", "ENTITIES_FDR" or "PUBCHEM_COMPOUND".

p_value

Set a P value threshold. Only results with P value equal to or less than your supplied threshold will be returned. (default = 1, Meaning no P value filtering)

min

(numeric) Minimum number of entities that a pathways should have to be included in the results.

max

(numeric) Maximum number of entities that a pathways should have to be included in the results.

...

rbioapi option(s). See rba_options's arguments manual for more information on available options.

Value

List with the results of the comparison.

Details

Reactome incorporate manually curated human reactions and PANTHER's protein homology data to Computationally infer events in other eukaryotic species.
In version 73 (11 June 2020), using an orthology-based approach, Homo sapiens events was projected to 18,654 orthologous pathways (with 81,835 orthologous proteins) in 15 non-human species. See Reactome Computationally Inferred Events for more information.

Corresponding API Resources

"GET https://reactome.org/AnalysisService/species/homoSapiens/species"

References

  • Fabregat A, Sidiropoulos K, Viteri G, Forner O, Marin-Garcia P, Arnau V, D'Eustachio P, Stein L, Hermjakob H. Reactome pathway analysis: a high-performance in-memory approach. BMC bioinformatics. 2017 Mar;18(1) 142. doi: 10.1186/s12859-017-1559-2. PubMed PMID: 28249561. PubMed Central PMCID: PMC5333408.

  • Reactome Analysis Services API Documentation

See also

Examples

# \donttest{
rba_reactome_analysis_species(species_dbid = 48892)
# }