Skip to contents

Participating molecules in a Reactome comprises set of 'Physical Entity' and 'Reference Entities' class objects. Use this function to retrieve all, only 'Physical Entity' or only 'Reference Entities' participants of given event.


  only_physical_entities = FALSE,
  only_reference_entities = FALSE,



Reactome event's database ID (DbId) or Stable ID (StId).


Logical: If TRUe, only participating 'Physical Entities' will be returned.


Logical: If TRUe, only participating 'Reference Entities' will be returned.


rbioapi option(s). See rba_options's arguments manual for more information on available options.


List with the participant of your supplied Event ID. A Data frame if only physical or 'Reference Entities' was requested.


A 'Physical Entity' Instance could include an individual molecule, a multi-molecular complex or a set of molecule forming a group based on some characteristics. a single molecule can have different 'Physical Entity' instances based on it's associated attributes. For example, IgK Ig kappa chain, has two 'Physical Entity' instances; one, with ID "R-HSA-197041" refers to the secreted antibody protein to the extra-cellular region; And the second one is with ID "R-HSA-2038819" and refers to the plasma-membrane-integrated form of the antibody protein.
To make it possible to link multiple 'Physical Entity' instances of a molecule, Reactome uses a data class named "'Reference Entities'" which correspond to the invariant attribute of a molecule. for example, both of the above-mentioned 'Physical Entities' see a 'Reference Entities' named "UniProt:P01834 IGKC.
See Reactome Data Model for more information about the data model and Physical Entities.

Corresponding API Resources

"GET participatingPhysicalEntities"
"GET referenceEntities"


  • Marc Gillespie, Bijay Jassal, Ralf Stephan, Marija Milacic, Karen Rothfels, Andrea Senff-Ribeiro, Johannes Griss, Cristoffer Sevilla, Lisa Matthews, Chuqiao Gong, Chuan Deng, Thawfeek Varusai, Eliot Ragueneau, Yusra Haider, Bruce May, Veronica Shamovsky, Joel Weiser, Timothy Brunson, Nasim Sanati, Liam Beckman, Xiang Shao, Antonio Fabregat, Konstantinos Sidiropoulos, Julieth Murillo, Guilherme Viteri, Justin Cook, Solomon Shorser, Gary Bader, Emek Demir, Chris Sander, Robin Haw, Guanming Wu, Lincoln Stein, Henning Hermjakob, Peter D’Eustachio, The reactome pathway knowledgebase 2022, Nucleic Acids Research, 2021;, kab1028,

  • Griss J, Viteri G, Sidiropoulos K, Nguyen V, Fabregat A, Hermjakob H. ReactomeGSA - Efficient Multi-Omics Comparative Pathway Analysis. Mol Cell Proteomics. 2020 Sep 9. doi: 10.1074/mcp. PubMed PMID: 32907876.

  • Reactome Content Services API Documentation

  • Citations note on Reactome website


# \donttest{
# }
# \donttest{
rba_reactome_participants("R-HSA-5682012", only_physical_entities = TRUE)
# }
# \donttest{
rba_reactome_participants("R-HSA-5682012", only_reference_entities = TRUE)
# }